Use of Different Parameters and Equations for Calculation of IC50 Values in Efflux Assays: Potential Sources of Variability in IC50 Determination

Author:

Volpe Donna A.,Hamed Salaheldin S.,Zhang Lei K.

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference57 articles.

1. Balimane PV, Marino A, Chong S. P-gp inhibition potential in cell-based models: which “calculation” method is the most accurate? AAPS J. 2008;10:577–86.

2. Food and Drug Administration (2012). Draft guidance. Guidance for industry: drug interaction studies—study design, data analysis, and implications for dosing and labeling. Available from http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm064982.htm . Accessed 28 October 2013.

3. European Medicine Agency. Guideline on the investigation of drug interactions. 2012. http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/document/document_detail.jsp?webContentId=WC500129606&mid=WC0b01ac058009a3dc . Accessed 28 October 2013.

4. Han HK. Role of transporters in drug interactions. Arch Pharmacol Res. 2011;34:1865–77.

5. Balimane PV, Han YH, Chong S. Current industrial practices of assessing permeability and P-glycoprotein interaction. AAPS J. 2006; 8(1):article 1.

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