Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram

Author:

Patel Nikunjkumar,Wiśniowska Barbara,Jamei Masoud,Polak Sebastian

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Reference44 articles.

1. Friesen KJ, Bugden SC. The effectiveness and limitations of regulatory warnings for the safe prescribing of citalopram. Drug Healthc Patient Saf. 2015;7:139–45. https://doi.org/10.2147/DHPS.S91046 .

2. US Food and Drug Adminstration. FDA drug safety communication: abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide). Silver Spring, MD: US Food and Drug Adminstration; 2011. http://www.fda.gov/Drugs/DrugSafety/ucm269086.htm .

3. US Food and Drug Adminstration. FDA drug safety communication: revised recommendations for Celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses. Silver Spring, MD: US Food and Drug Adminstration; 2012. https://www.fda.gov/Drugs/DrugSafety/ucm297391.htm .

4. Overø K, Hojelse F. The unexpected preclinical finding-elucidation of dog toxicity-citalopram. In Excerpts from a workshop on the use of pharmacology studies in drug safety assessment - present situation and future perspectives: September 26–27, Stockholm, Sweden. Stockholm: Association of the Swedish Pharmeceutical Industry (Lakemedelsindustriforen.) (LIF); Uppsala: Medical Products Agency [Lakemedelsverket]; 1994. p. 113–6.

5. Rohrbacher J, Bex P, Gallacher DJ. Citalopram metabolites inhibit IKs and IKr differentially: is this a possible explanation for the sudden deaths in dogs? J Pharmacol Toxicol Meth. 2012;66(2):170. https://doi.org/10.1016/j.vascn.2012.08.040 .

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