Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

Author:

He Yuhu123,Zuo Caojian34,Jia Daile35,Bai Peiyuan35,Kong Deping1,Chen Di3,Liu Guizhu6,Li Juanjuan3,Wang Yuanyang1,Chen Guilin1,Yan Shuai3,Xiao Bing3,Zhang Jian1,Piao Lingjuan3,Li Yanli1,Deng Yi1,Li Bin7,Roux Philippe P.89,Andreasson Katrin I.10,Breyer Richard M.1112,Su Yunchao13,Wang Jian6ORCID,Lyu Ankang5ORCID,Shen Yujun1ORCID,Yu Ying136ORCID

Affiliation:

1. Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

2. Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, Hunan, China

3. Chinese Academy of Sciences Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

4. Department of Cardiology, Shanghai General Hospital, and

5. Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

6. State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China

7. Orthopedic Institute, Soochow University, Jiangsu, China

8. Institute for Research in Immunology and Cancer and

9. Department of Pathology and Cell Biology, University of Montreal, Montreal, Quebec, Canada

10. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California

11. Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, Tennessee

12. Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; and

13. Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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