Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19

Author:

Sinnberg Tobias123ORCID,Lichtensteiger Christa4,Ali Omar Hasan451ORCID,Pop Oltin T.4ORCID,Jochum Ann-Kristin46ORCID,Risch Lorenz789ORCID,Brugger Silvio D.10ORCID,Velic Ana11ORCID,Bomze David412,Kohler Philipp13ORCID,Vernazza Pietro13ORCID,Albrich Werner C.13ORCID,Kahlert Christian R.1314ORCID,Abdou Marie-Therese4,Wyss Nina4,Hofmeister Kathrin1,Niessner Heike12ORCID,Zinner Carl15,Gilardi Mara15ORCID,Tzankov Alexandar15ORCID,Röcken Martin12ORCID,Dulovic Alex16ORCID,Shambat Srikanth Mairpady10ORCID,Ruetalo Natalia17,Buehler Philipp K.18ORCID,Scheier Thomas C.10,Jochum Wolfram6ORCID,Kern Lukas19,Henz Samuel20ORCID,Schneider Tino21,Kuster Gabriela M.22ORCID,Lampart Maurin22,Siegemund Martin2324ORCID,Bingisser Roland25ORCID,Schindler Michael17ORCID,Schneiderhan-Marra Nicole16ORCID,Kalbacher Hubert26ORCID,McCoy Kathy D.27ORCID,Spengler Werner28,Brutsche Martin H.18ORCID,Maček Boris11ORCID,Twerenbold Raphael2129ORCID,Penninger Josef M.530ORCID,Matter Matthias S.7ORCID,Flatz Lukas14311ORCID

Affiliation:

1. Department of Dermatology,

2. Cluster of Excellence iFIT (EXC 2180) Image Guided and Functionally Instructed Tumor Therapies,

3. Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany;

4. Institute of Immunobiology,

5. Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada;

6. Institute of Pathology,

7. Center of Laboratory Medicine, Vaduz, Liechtenstein;

8. Center of Laboratory Medicine, University Institute of Clinical Chemistry, University Hospital Bern, University of Bern, Bern, Switzerland;

9. Faculty of Medical Sciences, Private University in the Principality of Liechtenstein, Triesen, Liechtenstein;

10. Department of Infectious Diseases and Hospital Hygiene, and

11. Proteome Center Tübingen, Interfaculty Institute for Cell Biology,

12. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;

13. Division of Infectious Diseases and Hospital Epidemiology,

14. Department of Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland;

15. Pathology, Institute of Medical Genetics and Pathology,

16. NMI Natural and Medical Sciences Institute, and

17. Institute for Medical Virology and Epidemiology, and

18. Institute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland;

19. Lung Center,

20. Department of Internal Medicine,

21. Division of Pneumology, and

22. Department of Cardiology and Cardiovascular Research Institute Basel (CRIB),

23. Intensive Care Unit, Department of Acute Medicine,

24. Department of Clinical Research, and

25. Emergency Department, University Hospital Basel, University of Basel, Basel, Switzerland;

26. Institute of Clinical Anatomy and Cell Analysis, University of Tübingen, Tübingen, Germany;

27. Snyder Institute for Chronic Disease, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;

28. Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany;

29. University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Partner Site Hamburg-Kiel-Lübeck, Hamburg, Germany; and

30. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria

31. Department of Dermatology, Venereology, and Allergology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland;

Funder

Swiss National Science Foundation

Research Fund of the Cantonal Hospital St. Gallen

Lungenliga St. Gallen–Appenzell

Deutsche Forschungsgemeinschaft

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Fondation Botnar

Promedica Foundation grant

Austrian Science Fund

Innovative Medicines Canada

Canada 150 Research Chairs Program

Canadian Institutes of Health Research

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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