Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial

Author:

Gorman Ellen A.1ORCID,Rynne Jennifer2ORCID,Gardiner Hannah J.1,Rostron Anthony J.34ORCID,Bannard-Smith Jonathan5ORCID,Bentley Andrew M.6ORCID,Brealey David7ORCID,Campbell Christina8ORCID,Curley Gerard9ORCID,Clarke Mike8ORCID,Dushianthan Ahilanadan1011ORCID,Hopkins Phillip12ORCID,Jackson Colette8,Kefela Kallirroi13,Krasnodembskaya Anna1ORCID,Laffey John G.14ORCID,McDowell Cliona8,McFarland Margaret15,McFerran Jamie8,McGuigan Peter115,Perkins Gavin D.1617ORCID,Silversides Jonathan115ORCID,Smythe Jon18,Thompson Jacqui19,Tunnicliffe William S.20,Welters Ingeborg D.M.2122ORCID,Amado-Rodríguez Laura232425ORCID,Albaiceta Guillermo23242526ORCID,Williams Barry27,Shankar-Hari Manu2ORCID,McAuley Daniel F.115ORCID,O’Kane Cecilia M.1ORCID

Affiliation:

1. Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, United Kingdom;

2. Centre for Inflammation Research, The University of Edinburgh, Edinburgh, United Kingdom;

3. Sunderland Royal Hospital, South Tyneside and Sunderland National Health Service Foundation Trust, Sunderland, United Kingdom;

4. Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom;

5. Department of Critical Care, Manchester Royal Infirmary, Manchester, United Kingdom;

6. Acute Intensive Care Unit, Wythenshawe Hospital, Manchester, United Kingdom;

7. University College Hospital London, London, United Kingdom;

8. Northern Ireland Clinical Trials Unit, Belfast, United Kingdom;

9. Royal College of Surgeons in Ireland, Dublin, Ireland;

10. University Hospital Southampton, Southampton, United Kingdom;

11. National Institute for Health and Care Research Southampton Biomedical Research Centre, University of Southampton, Southampton, United Kingdom;

12. King’s Trauma Centre, King’s College Hospital, London, United Kingdom;

13. Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom;

14. Regenerative Medicine Institute at CÚRAM Centre for Research in Medical Devices, University of Galway, Galway, Ireland;

15. Department of Critical Care, Belfast Health and Social Care Trust, Belfast, United Kingdom;

16. Critical Care Unit, University Hospitals Birmingham, Birmingham, United Kingdom;

17. Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, United Kingdom;

18. National Health Service Blood and Transplant, Oxford, United Kingdom;

19. National Health Service Blood and Transplant, Birmingham, United Kingdom;

20. Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom;

21. Intensive Care Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom;

22. Institute of Life Course Medical Sciences, University of Liverpool, Liverpool Centre for Cardiovascular Science, Liverpool, United Kingdom;

23. Centro de Investigación Biomédica en Red–Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain;

24. Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain;

25. Unidad de Cuidados Intensivos Cardiológicos, Hospital Universitario Central de Asturias, Oviedo, Spain;

26. Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain; and

27. Independent Patient and Public Representative, Sherborne, United Kingdom

Funder

Wellcome Trust

Northern Ireland Health and Social Care Research and Development Fund

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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