Author:
McMullan Ross R.,McAuley Daniel F.,O’Kane Cecilia M.,Silversides Jonathan A.
Abstract
AbstractSepsis is a life-threatening condition characterised by endothelial barrier dysfunction and impairment of normal microcirculatory function, resulting in a state of hypoperfusion and tissue oedema. No specific pharmacological therapies are currently used to attenuate microvascular injury. Given the prominent role of endothelial breakdown and microcirculatory dysfunction in sepsis, there is a need for effective strategies to protect the endothelium. In this review we will discuss key mechanisms and putative therapeutic agents relevant to endothelial barrier function.
Funder
Medical Research Council
British Journal of Anaesthesia
Royal College of Anaesthetists
Publisher
Springer Science and Business Media LLC
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