Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease

Author:

Sulaiman Imran1234ORCID,Wu Benjamin G.125,Chung Matthew6,Isaacs Bradley12,Tsay Jun-Chieh J.125,Holub Meredith127,Barnett Clea R.12,Kwok Benjamin12,Kugler Matthias C.12ORCID,Natalini Jake G.12,Singh Shivani12,Li Yonghua12,Schluger Rosemary12,Carpenito Joseph12,Collazo Destiny12,Perez Luisanny12,Kyeremateng Yaa12,Chang Miao12,Campbell Christina D.34,Hansbro Philip M.8,Oppenheimer Beno W.12,Berger Kenneth I.12,Goldring Roberta M.12,Koralov Sergei B.9,Weiden Michael D.12,Xiao Rui10,D’Armiento Jeanine10,Clemente Jose C.11,Ghedin Elodie6ORCID,Segal Leopoldo N.1212ORCID

Affiliation:

1. Division of Pulmonary and Critical Care Medicine,

2. Department of Medicine,

3. Department of Respiratory Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland;

4. Department of Respiratory Medicine, Beaumont Hospital, Dublin, Ireland;

5. Division of Pulmonary and Critical Care Medicine, Veterans Affairs (VA) New York Harbor Healthcare System, New York, New York;

6. Systems Genomics Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;

7. Division of Pulmonary and Critical Care Medicine, Hartford Health Care, Hartford, Connecticut;

8. Centre for Inflammation, Centenary Institute and University of Technology Sydney, School of Life Sciences, Sydney, New South Wales, Australia;

9. Department of Pathology, and

10. Department of Physiology and Cellular Biophysics, Columbia University School of Medicine, New York, New York; and

11. Department of Genetics and Genomic Sciences and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York

12. Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, New York University (NYU) Langone Health, New York, New York;

Funder

National Cancer Institute/NIH

National Heart, Lung, and Blood Institute/NIH

Foundation for the NIH

National Center for Advancing Translational Science

NIH

American Association for Cancer Research

Cancer Center Support Grant

Flight Attendant Medical Research Institute

Stony Wold-Herbert Fund

Will Rogers Research Fellowship

NIAID/NIH

National Health and Medical Research Council Australia

Cancer Council NSW and UTS

Publisher

American Thoracic Society

Subject

Critical Care and Intensive Care Medicine,Pulmonary and Respiratory Medicine

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