Fentanyl and its derivatives as a group of new psychoactive substances (designer drugs)

Abstract

Fentanyl has been known for many years. It has been widely used in emergency medicine and anaesthesiology. Due to its strong action, it gained a reputation of a popular addictive drug. Over the past years, fentanyl derivatives, produced as new psychoactive substances (designer drugs), have become a growing problem in clinical and forensic toxicology due to their non-therapeutic use. Both the variability in the construction of fentanyls and, consequently, the change in toxokinetic properties, as well as their high toxicity, often lead people to take this group of compounds to fatal intoxication. The purpose of this paper is to present various formulations of fentanyl and to discuss the properties of fentanyl and its derivatives, with particular emphasis on the toxicity of this group of compounds. Reviewing the available literature, the authors also focused on presenting the therapeutic concentrations of fentanyl and its most popular analogues, comparing them with the concentrations observed in lethal opioid poisonings.