Abstract
Abstract
Oxidative stress caused by an overproduction of reactive oxygen species (ROS) is the key factor in developing a variety of pathological conditions. Recently various nanomaterials have attracted growing interest as nanoantioxidants with ROS-regulating ability. Here, for the first time, we report on high antioxidant behavior (enzyme-like activity) of GdYVO4:Eu3+ nanoparticles (GdYVO NPs) revealed by spectroscopic methods both in cell-free and biological milieu using various ROS sensors. It was revealed that GdYVO NPs (d = 2 nm) effectively scavenge hydroxyl radicals
·
O
H
,
superoxide anions
O
2
·
−
,
hydrogen peroxide
H
2
O
2
,
peroxyl radicals
R
O
O
·
,
and remarkably reduce the lipopolysaccharide-induced ROS generation in rat leukocytes. The antioxidant activity of GdYVO NPs is ascribed to high amount of V4+ and V3+ ions in the structure of the NPs and the reversible switching
V
3
+
↔
V
4
+
and
V
4
+
↔
V
5
+
vanadium oxidation states.
Funder
Ministry of Health of Ukraine
National Research Foundation of Ukraine
Subject
Electrical and Electronic Engineering,Mechanical Engineering,Mechanics of Materials,General Materials Science,General Chemistry,Bioengineering
Cited by
15 articles.
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