Label free detection of uric acid using Si nanowire PH sensor

Abstract

Abstract In this study, we successfully apply a silicon nanowire FETs biosensor for detection of uric acid according to pH change. The pH sensing experiments of the silicon nanowire FETs shows that average sensitivity of 42mV/pH. We show that silicon nanowire FETs configured as pH sensors can be used for the quantitative detection of uric acid at concentration as low as 2.4mg/dL. The sensor shows a good linearity (R2 = 0.99) and sensitivity (60mV/mM) in the concentration range of 3-8mg/dL, with less than 300 sec response time. These results demonstrate that silicon nanowire FETs based biosensor can potentially be served as the diagnosis tool for general clinical examinations.