Voltammetric Determination of Paracetamol using Polyvinyl Alcohol (PVA)-Fe3O4 Modified Glassy Carbon Electrode

Abstract

Abstract Modifications of glassy carbon electrodes (GCE) as working electrodes have been carried out by polyvinyl alcohol (PVA)-Fe3O4 membranes. The PVA-Fe3O4 membrane was superimposed on the surface of a glassy carbon electrode. This study influences the percentage of paracetamol in the membrane, the effect of modulation time, the effect of modulation amplitude, the effect of scan rate, the effect of pH and supporting electrolytes. The performance evaluation of the modified electrode was based on a voltammogram of cyclic voltammetry (CV) and the analysis was carried out with a differential pulse voltammetry (DPV) method. The effect of pH was studied in the range of 2-7 by Britton – Robinson buffer. The results showed that the percentage of paracetamol in the membrane affected the diffusion of current. The best performance of GCE modified was produced by a membrane with paracetamol percentage of 3% (w/w). The optimum operational condition of the instrument was at modulation amplitude of 10 mV, the modulation time of 0.1 s and the scan rate of 12.5 mV/s. pH affects the shift of the anodic peak of paracetamol in a more negative direction. The results of the analysis of paracetamol using DPV method showed that more sensitivity was achieved when phosphate buffer as a supporting electrolyte was used. The sensitivity of the GCE modified by the PVA-Fe3O4 membrane was 0.2922 µA/µM in the linear concentration range of 0-100 µM and limit of detection (LoD) of 8 µM.