Rhodomyrtus Tomentosa Extract Activity on Diabetic Wound

Abstract

Abstract Karamunting (Rhodomyrtus tomentosa (Aiton) Hassk) is a plant that is widely used as a traditional medicine for, among others, wound healing. This study aims to determine the activity of ethanol extract ointment of 70% karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk) and its ability on topical healing of diabetic wounds. A total of 48 rats were divided into 6 treatment groups, namely karamunting leaf extract ointment 2.5%, 5%, and 10%, diabetic control, non-diabetic control, and honey. The data obtained were the number of inflammatory cells, the number of fibroblasts, collagen density and epithelial thickness which were observed in days 3, 7, 10 and 14 days after the making of the wound. Based on histological observations, the results showed that the application of ethanol extract ointment with 70% karamunting leaf could affect the number of inflammatory cells, fibroblasts, and collagen density as well as significant re-epithelization speed compared to diabetes controls. Of the three concentrations tested, ointment at a concentration of 10% showed comparable results to honey. It can therefore be concluded that the application of ethanol extract ointment of 70% karamunting leaves can increase the speed of healing diabetic wounds.