Cp*Co(III)-catalyzed C-H bond amination of indoles with arylazide compounds

Abstract

Abstract Indoles are an important class of intermediates found in drug molecules and functional materials, so structural modification of indoles is necessary. We have developed an inexpensive and readily available transition metal cobalt(III) catalyzed selective C-H amination reaction of indoles with azides at the C2 position, which has high functional group tolerance. It provides an effective way to synthesize a range of 2-aminoindole derivatives using an environmentally friendly and resource-efficient catalytic system, paving the way for expanding the application of indole structures.