Anti-Inflammatory Activity of Fern Pteridium aquilinum Ethanol Extract Gel on Mice (Mus musculus) Incision Wounds

Abstract

Abstract The utilization of natural resources around the community is one of the alternative anti-inflammatory medications. One of the several studies on this area reported that commonly people use Pteridium aquilinum leaves to heal wound instead of commercial gel medications. The research aimed to determine the activity and it effective dose of Pteridium aquilinum ethanol extract gel as an anti-inflammatory. The ethanol extract of Pteridium aquilinum was formulated in a gel with varying dosage concentrations of 1%, 1.5%, and 3% for 2 times applied a day in 14 days, with the incision wounds without fern ethanol extract gel as negative control and incision wound was treated with commercially as positive control. Observation on the wound length and the injured tissue histology of mice incision wound carried out on 3, 5, 7, and 14 days of treatment. The results prove that fern ethanol extract gel formula has anti-inflammatory activity on mice incision wound. Wound healing indicated by the closure of the wound on the skin. Based on the results can be concluded that Pteridium aquilinum ethanol extract has anti-inflammatory and heals mice incision wound affectively in 14 days with the best dosage concentration of 3%.