Effects of ciprofloxacin on chicken blood parameters after an experimental infection

Abstract

Abstract The objective of this paper is to study the dynamics of blood parameters in chicken resulting from use of Ciprofloxacin. Ciprofloxacin is more active in affecting aerobic Gram-negative bacteria and Staphylococci. To study the dynamics, formed three groups of chickens (1st group — control; 2nd and 3rd groups – experimental groups), which included crossbred Hisex Brown roosters. The experimental infection of chickens in the 2nd and 3rd group with Staphylococcus aureus culture performed. One day before and during four days after infection chickens in the 3rd group received 200 mg/L of Ciprofloxacin dissolved in water. Blood samples were drawn from all subjects on the day of infection, and then at the 2nd, 4th and 6th day after infection. The following blood parameters: red blood cell count, hemoglobin level, white blood cell count, and leucograms were studied. Analysis of the data we obtained showed significant changes in some parameters of white blood cells in the 2nd and third groups in comparison to the control group. We found inflammatory response which was characterized by significant increase in the absolute count and percentage of pseudo-eosinophils, monocytes and basophils in the 2nd and 3rd groups in comparison to the control group.