Abstract
Abstract
Electrochemical sensors can be used to detect neurotransmitters. A miniature potentiometric all-solid-state coated wire dopamine sensor was investigated in this work. Conducting polymer poly (3,4- ethylenedioxythiophene) doped with poly (styrenesulfonate) as the solid contact was electropolymerized on one end of a gold wire (diameter 0.25 mm). The conducting polymer was covered with a dopamine-selective membrane containing 12-crown-4-tetraphenylborate as a neutral carrier, 2-nitrophenyloctyl ether as a plasticizer and poly (vinyl chloride) as the membrane matrix. The dopamine sensor covered a wide linear range from 10–5 M to 10–1 M with a slope of 53.85 ± 0.93 mV/decade, while the detection limit was 5.80 ± 0.31 µM. The other characteristics of the dopamine sensor were also evaluated. The experimental results showed that the sensor operated properly within the pH range of 5.5–7.5 and displayed good selectivity, fast dynamic response, high reproducibility and long stability. In addition, the dopamine sensor was successfully applied for the detection of dopamine in artificial cerebrospinal fluid by using the standard addition method, indicating that this sensor is promising for applications in dopamine determination in neuroscientific research.
Funder
Natural Science Foundation of Zhejiang Province
National Natural Science Foundation of China
Subject
Applied Mathematics,Instrumentation,Engineering (miscellaneous)
Cited by
5 articles.
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