Multi-scale pulsatile CFD modeling of thrombus transport in a patient-specific LVAD implantation

Abstract

Purpose Predictive models implemented in medical procedures can potentially bring great benefit to patients and represent a step forward in targeted treatments based on a patient’s physiological condition. It is the purpose of this paper to outline such a model. Design/methodology/approach A multi-scale 0D-3D model based on patient specific geometry combines a 0-dimensional lumped parameter model (LPM) with a 3D computational fluid dynamics (CFD) analysis coupled in time, to obtain physiologically viable flow parameters. Findings A comparison of physiological data gathered from literature with flow-field measurements in this model shows the viability of this method in relation to potential predictions of pathological flows repercussions and candidate treatments. Research limitations/implications A limitation of the model is the absence of compliance in the walls in the CFD fluid domain; however, compliance of the peripheral vasculature is accounted for by the LPM. Currently, an attempt is in progress to extend this multi-scale model to account for the fluid-structure interaction of the ventricular assist device vasculature and hemodynamics. Originality/value This work reports on a predictive pulsatile flow model that can be used to investigate surgical alternatives to reduce strokes in LVADs.