Abstract
Microrobotics extends the reach of human-controlled machines to submillimeter dimensions. We introduce a microrobot that relies on optoelectronic tweezers (OET) that is straightforward to manufacture, can take nearly any desirable shape or form, and can be programmed to carry out sophisticated, multiaxis operations. One particularly useful program is a serial combination of “load,” “transport,” and “deliver,” which can be applied to manipulate a wide range of micrometer-dimension payloads. Importantly, microrobots programmed in this manner are much gentler on fragile mammalian cells than conventional OET techniques. The microrobotic system described here was demonstrated to be useful for single-cell isolation, clonal expansion, RNA sequencing, manipulation within enclosed systems, controlling cell–cell interactions, and isolating precious microtissues from heterogeneous mixtures. We propose that the optoelectronic microrobotic system, which can be implemented using a microscope and consumer-grade optical projector, will be useful for a wide range of applications in the life sciences and beyond.
Publisher
Proceedings of the National Academy of Sciences
Reference49 articles.
1. A biologically inspired, flapping-wing, hybrid aerial-aquatic microrobot;Chen;Sci. Robot.,2017
2. Multifunctional biohybrid magnetite microrobots for imaging-guided therapy;Yan;Sci. Robot.,2017
3. Micro/nanorobots for biomedicine: Delivery, surgery, sensing, and detoxification;Li;Sci. Robot.,2017
4. A photon-driven micromotor can direct nerve fibre growth;Wu;Nat. Photonics,2017
5. Light-driven micro-tool equipped with a syringe function;Villangca;Light Sci. Appl.,2016
Cited by
89 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献