Abstract
Local control of neuronal activity is central to many therapeutic strategies aiming to treat neurological disorders. Arguably, the best solution would make use of endogenous highly localized and specialized regulatory mechanisms of neuronal activity, and an ideal therapeutic technology should sense activity and deliver endogenous molecules at the same site for the most efficient feedback regulation. Here, we address this challenge with an organic electronic multifunctional device that is capable of chemical stimulation and electrical sensing at the same site, at the single-cell scale. Conducting polymer electrodes recorded epileptiform discharges induced in mouse hippocampal preparation. The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), was then actively delivered through the recording electrodes via organic electronic ion pump technology. GABA delivery stopped epileptiform activity, recorded simultaneously and colocally. This multifunctional “neural pixel” creates a range of opportunities, including implantable therapeutic devices with automated feedback, where locally recorded signals regulate local release of specific therapeutic agents.
Funder
Seventh Framework Programme
Fondation Aix-Marseille Universite
VINNOVA
Vetenskapsrådet
Knut och Alice Wallenbergs Stiftelse
National Science Foundation
Agence Nationale de la Recherche
Fondation de l'Avenir pour la Recherche Medicale Appliquee
Publisher
Proceedings of the National Academy of Sciences
Cited by
102 articles.
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