Remodeling of lateral geniculate nucleus projections to extrastriate area MT following long-term lesions of striate cortex

Abstract

Significance Lesions of the primary visual area (V1) in primates cause blindness by severing the main pathway which brings information from the thalamus to the cortex. However, some visual abilities remain, which are hypothesized to be mediated by thalamic neurons that innervate surviving areas such as the middle temporal (MT) cortex. We found that V1 lesions trigger long-term plasticity in the connections between the thalamus and cortex, including the emergence of a pathway that brings information to MT from cell populations that would normally project to V1. These results reveal potential targets for rehabilitation strategies to ameliorate the consequences of cortical blindness.