Specialized interferon action in COVID-19-Reference-Cited by-同舟云学术

Specialized interferon action in COVID-19

Published:2022-02-25 Issue:11 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Galbraith Matthew D.¹²^ORCID,Kinning Kohl T.¹^ORCID,Sullivan Kelly D.¹³,Araya Paula¹,Smith Keith P.¹,Granrath Ross E.¹,Shaw Jessica R.¹,Baxter Ryan⁴,Jordan Kimberly R.⁴^ORCID,Russell Seth⁵^ORCID,Dzieciatkowska Monika⁶,Reisz Julie A.⁶,Gamboni Fabia⁶^ORCID,Cendali Francesca⁶^ORCID,Ghosh Tusharkanti⁷,Guo Kejun⁸^ORCID,Wilson Cara C.⁸^ORCID,Santiago Mario L.⁸^ORCID,Monte Andrew A.⁹,Bennett Tellen D.¹⁰^ORCID,Hansen Kirk C.⁶^ORCID,Hsieh Elena W. Y.⁴¹¹^ORCID,D’Alessandro Angelo⁶,Espinosa Joaquin M.¹²

Affiliation:

1. Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

2. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

3. Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

4. Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

5. Data Science to Patient Value, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

6. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

7. Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO 80045

8. Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

9. Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

10. Department of Pediatrics, Sections of Informatics and Data Science and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

11. Department of Pediatrics, Section of Allergy/Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045

Abstract

Significance The interferon (IFN) family of proteins plays key roles in the immune response against viruses and other pathogens. In the context of COVID-19, IFNs have been shown to be key for restraining SARS-CoV-2 infection but have also been described as drivers of severe symptoms. However, it is not fully understood how each member of the IFN family contributes to distinct aspects of COVID-19. We report here the results of a deep examination of 12 different IFNs in hospitalized COVID-19 patients, which revealed clear differences among IFNs in their associations with molecular, cellular, and physiological processes relevant to COVID-19 presentation.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2116730119