Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles-Reference-Cited by-同舟云学术

Dopamine D2 receptor signaling in the brain modulates circadian liver metabolomic profiles

Published:2022-03-10 Issue:11 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Cervantes Marlene¹²^ORCID,Lewis Robert G.¹³^ORCID,Della-Fazia Maria Agnese⁴^ORCID,Borrelli Emiliana¹³,Sassone-Corsi Paolo¹²

Affiliation:

1. INSERM U1233, Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697

2. Department of Biological Chemistry, University of California, Irvine, CA 92697

3. Department of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697

4. Department of Medicine and Surgery, University of Perugia, Perugia 06132, Italy

Abstract

Significance We analyzed the liver metabolome of mice deficient in the expression of the dopamine D2 receptor (D2R) in striatal medium spiny neurons (iMSN-D2RKO) and found profound changes in the liver circadian metabolome compared to control mice. Additionally, we show activation of dopaminergic circuits by acute cocaine administration in iMSN-D2RKO mice reprograms the circadian liver metabolome in response to cocaine. D2R signaling in MSNs is key for striatal output and essential for regulating the first response to the cellular and rewarding effects of cocaine. Our results suggest changes in dopamine signaling in specific striatal neurons evoke major changes in liver physiology. Dysregulation of liver metabolism could contribute to an altered allostatic state and therefore be involved in continued use of drugs.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2117113119

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