Circadian regulation of liver metabolism: experimental approaches in human, rodent, and cellular models

Author:

Daniels Lorna J.1ORCID,Kay Danielle1,Marjot Thomas1,Hodson Leanne12ORCID,Ray David W.123

Affiliation:

1. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

2. NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom

3. Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, United Kingdom

Abstract

Over the past decade, there has been an increased interest in understanding the intricate relationship between circadian rhythm and liver metabolism. In this review, we have systematically searched the literature to analyze the various experimental approaches utilizing human, rodent, and in vitro cellular approaches to dissect the link between liver circadian rhythms and metabolic disease.

Funder

British Heart Foundation

Novo Nordisk

Wellcome Trust

Publisher

American Physiological Society

Subject

Cell Biology,Physiology

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