Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets-Reference-Cited by-同舟云学术

Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets

Published:2022-04-27 Issue:18 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Okimura Chika¹^ORCID,Iwanaga Misaki¹^ORCID,Sakurai Tatsunari²^ORCID,Ueno Tasuku³^ORCID,Urano Yasuteru³⁴^ORCID,Iwadate Yoshiaki¹^ORCID

Affiliation:

1. Department of Biology, Yamaguchi University, Yamaguchi 753-8512, Japan

2. Department of Mathematical Engineering, Musashino University, Tokyo 135-8181, Japan

3. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan

4. Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan

Abstract

Significance Collective cell migration is an important phenomenon in the developmental process of living organisms and even in mature individuals. The cells in the collective are accurately classified into leader cells, which lead the collective at the leading edge, and follower cells. We found that in the collective migration of keratocytes, the epidermal cells of fish responsible for wound repair, a mechanical interaction between two leader cells and a single follower cell can forcibly break the connection between the two leader cells and transform the follower cell into a leader cell.

Funder

Ministry of Education, Culture, Sports, Science and Technology

JSPS Core-to-Core Program

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2119903119

Reference50 articles.

1. Collective cell migration in morphogenesis, regeneration and cancer

2. The front and rear of collective cell migration