Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment-Reference-Cited by-同舟云学术

Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment

Published:2022-01-19 Issue:4 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Bhattacharjee Maumita¹²³,Escobar Ivirico Jorge L.²³⁴,Kan Ho-Man¹²³,Shah Shiv¹²⁴,Otsuka Takayoshi¹²³^ORCID,Bordett Rosalie⁵,Barajaa Mohammed¹²³,Nagiah Naveen¹²³,Pandey Rishikesh⁵⁶,Nair Lakshmi S.¹²³⁶⁷,Laurencin Cato T.¹²³⁴⁶^ORCID

Affiliation:

1. Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT 06030

2. Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030

3. Department of Orthopaedic Surgery, University of Connecticut Health, Farmington, CT 06030

4. Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269

5. Connecticut Children's Innovation Center, School of Medicine, University of Connecticut Health, Farmington, CT 06032

6. Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269

7. Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269

Abstract

Significance Osteoarthritis (OA) is a chronic disease affecting millions of people worldwide with no curative solution. In the present study, we developed a minimally invasive injectable system using amnion membrane (AM) from the human placenta as a carrier for fat tissue-derived stem cells (adipose-derived stem cells [ADSCs]) to treat OA. Both AM and ADSCs are rich sources of bioactive molecules that can target the sites of inflammation and reduce the inflammation-driven articular cartilage damage. Our study demonstrated the disease-modifying and regenerative potential of AM hydrogel, a comparable regenerative and disease-modifying effect of AM hydrogel and ADSCs, and the synergistic effect of AM with ADSCs in regenerating cartilage and attenuating OA.

Funder

HHS | National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2120968119

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