Structure and function of the hippocampal CA3 module-Reference-Cited by-同舟云学术

Structure and function of the hippocampal CA3 module

Published:2024-01-30 Issue:6 Volume:121 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Sammons Rosanna P.¹^ORCID,Vezir Mourat²,Moreno-Velasquez Laura¹^ORCID,Cano Gaspar³^ORCID,Orlando Marta¹^ORCID,Sievers Meike⁴,Grasso Eleonora²^ORCID,Metodieva Verjinia D.¹^ORCID,Kempter Richard³⁵⁶^ORCID,Schmidt Helene²,Schmitz Dietmar¹⁵⁶⁷⁸^ORCID

Affiliation:

1. Neuroscience Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Neuroscience Research Center, Berlin 10117, Germany

2. Ernst Strüngmann Institute for Neuroscience, Frankfurt am Main 60528, Germany

3. Institute for Theoretical Biology, Department of Biology, Humboldt-Universität zu Berlin, Berlin 10115, Germany

4. Department of Connectomics, Max Planck Institute for Brain Research, Frankfurt am Main 60438, Germany

5. Bernstein Center for Computational Neuroscience Berlin, Berlin 10115, Germany

6. Einstein Center for Neurosciences Berlin, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Einstein Center for Neurosciences Berlin, Berlin 10117, Germany

7. German Center for Neurodegenerative Diseases Berlin, Berlin 10117, Germany

8. Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany

Abstract

The hippocampal formation is crucial for learning and memory, with submodule CA3 thought to be the substrate of pattern completion. However, the underlying synaptic and computational mechanisms of this network are not well understood. Here, we perform circuit reconstruction of a CA3 module using three dimensional (3D) electron microscopy data and combine this with functional connectivity recordings and computational simulations to determine possible CA3 network mechanisms. Direct measurements of connectivity schemes with both physiological measurements and structural 3D EM revealed a high connectivity rate, multi-fold higher than previously assumed. Mathematical modelling indicated that such CA3 networks can robustly generate pattern completion and replay memory sequences. In conclusion, our data demonstrate that the connectivity scheme of the hippocampal submodule is well suited for efficient memory storage and retrieval.

Funder

Deutsche Forschungsgemeinschaft

EC | ERC | HORIZON EUROPE European Research Council

Bundesministerium für Bildung und Forschung

Publisher

Proceedings of the National Academy of Sciences

Link

https://pnas.org/doi/pdf/10.1073/pnas.2312281120

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