Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation-Reference-Cited by-同舟云学术

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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

Published:2014-04-07 Issue:16 Volume:111 Page:5884-5889
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Ng A. P.,Kauppi M.,Metcalf D.,Hyland C. D.,Josefsson E. C.,Lebois M.,Zhang J.-G.,Baldwin T. M.,Di Rago L.,Hilton D. J.,Alexander W. S.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference35 articles.

1. Primary Role of the Liver in Thrombopoietin Production Shown by Tissue-Specific Knockout

2. Regulation of hematopoietic stem cells by their mature progeny

3. Incomplete restoration of Mpl expression in the mpl−/− mouse produces partial correction of the stem cell–repopulating defect and paradoxical thrombocytosis

4. Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes

5. Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction

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