Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET-Reference-Cited by-同舟云学术

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Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Published:2011-01-24 Issue:6 Volume:108 Page:2593-2598
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Kannan P.,Brimacombe K. R.,Kreisl W. C.,Liow J.-S.,Zoghbi S. S.,Telu S.,Zhang Y.,Pike V. W.,Halldin C.,Gottesman M. M.,Innis R. B.,Hall M. D.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference33 articles.

1. Multidrug resistance in cancer: role of ATP–dependent transporters

2. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

3. N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier

4. P-Glycoprotein Function at the Blood–Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide

5. Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases;Translational Neurodegeneration;2023-06-08

2. Influence of P-glycoprotein on pulmonary disposition of the model substrate [11C]metoclopramide assessed by PET imaging in rats;European Journal of Pharmaceutical Sciences;2023-04

3. ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery;Pharmacological Reviews;2023-03-27

4. Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?;Journal of Cerebral Blood Flow & Metabolism;2021-09-09

5. Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines;Fluids and Barriers of the CNS;2021-08-03

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