Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function-Reference-Cited by-同舟云学术

Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

Published:2008-09-11 Issue:19 Volume:51 Page:6034-6043
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lazarova Neva¹,Zoghbi Sami S.¹,Hong Jinsoo¹,Seneca Nicholas¹,Tuan Ed¹,Gladding Robert L.¹,Liow Jeih-San¹,Taku Andrew¹,Innis Robert B.¹,Pike Victor W.¹

Affiliation:

1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800510m

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4. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

5. Multidrug resistance in cancer: role of ATP–dependent transporters

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