Rapid deletion of rearranged T cell antigen receptor (TCR) V -J segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR chain gene and positive selection in the T cell repertoire formation-Reference-Cited by-同舟云学术

Rapid deletion of rearranged T cell antigen receptor (TCR) V -J segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR chain gene and positive selection in the T cell repertoire formation

Published:1998-09-29 Issue:20 Volume:95 Page:11834-11839
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Wang F.,Huang C.-Y.,Kanagawa O.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference24 articles.

1. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes

2. Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

3. A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition

4. Exclusion and inclusion of α and β T cell receptor alleles

5. The joining of germ-line Vα to Jα genes replaces the preexisting Vα-Jα complexes in a T cell receptor α,β positive T cell line

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