Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

Author:

Harding Heather P.,Zhang Yuhong,Scheuner Donalyn,Chen Jane-Jane,Kaufman Randal J.,Ron David

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference41 articles.

1. Hinnebusch AG (2000) Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. Translational Control of Gene Expression, eds Sonenberg N Hershey JWB Mathews MB (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY), pp 185–243.

2. Ron D Harding H (2007) eIF2a phosphorylation in cellular stress responses and disease. Translational Control, eds Sonenberg N Hershey J Mathews M (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY) Cold Spring Harbor Monograph Series, pp 345–368.

3. NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation

4. Regulation of protein synthesis by the heme-regulated eIF2α kinase: relevance to anemias

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