Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cells
Author:
Funder
National Science Foundation
Publisher
Springer Science and Business Media LLC
Link
https://link.springer.com/content/pdf/10.1007/s00253-024-13281-5.pdf
Reference40 articles.
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2. Chung C-H, Murphy CM, Wingate VP, Pavlicek JW, Nakashima R, Wei W, McCarty D, Rabinowitz J, Barton E (2023) Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells. Mol Ther-Methods Clin Dev 28:272–283
3. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P (2005) On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acd Sci 102(52):18773–18784
4. De BP, Cram S, Lee H, Rosenberg JB, Sondhi D, Crystal RG, Kaminsky SM (2023) Assessment of residual full-length SV40 large T antigen in clinical-grade adeno-associated virus vectors produced in 293T cells. Hum Gene Ther 34(15–16):697–704
5. Escandell J, Moura F, Carvalho SB, Silva RJ, Correia R, Roldão A, Gomes-Alves P, Alves PM (2023) Towards a scalable bioprocess for rAAV production using a HeLa stable cell line. Biotechnol Bioeng 120(9):2578–2587
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