Calibration-free, high-precision, and robust terahertz ultrafast metasurfaces for monitoring gastric cancers

Author:

Lou Jing1234,Jiao Yanan35,Yang Ruisheng16,Huang Yindong3ORCID,Xu Xing3,Zhang Lei78ORCID,Ma Zhaofu35,Yu Ying4,Peng Wenyu3,Yuan Yifang3,Zhong Yuan3,Li Songyan5,Yan Yang5,Zhang Fuli6ORCID,Liang Jiangang4,Du Xiaohui5,Chang Chao23ORCID,Qiu Cheng-Wei19ORCID

Affiliation:

1. Department of Electrical and Computer Engineering, National University of Singapore, 117583 Singapore, Singapore

2. School of Physics, Peking University, 100871 Beijing, China

3. Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, 100071 Beijing, China

4. Air and Missile Defense College, Air Force Engineering University, 710051 Xi’an, China

5. Department of General Surgery, First Medical Center, Chinese People's Liberation Army (PLA) General Hospital, 100853 Beijing, China

6. School of Physical Science and Technology, Northwestern Polytechnical University, Xi’an, China

7. Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Electronic Science and Engineering, Xi’an Jiaotong University, 710049 Xi’an, China

8. Shanxi Key Laboratory of Information Photonic Technique, School of Electronic Science and Engineering, Xi’an Jiaotong University, 710049 Xi’an, China

9. National University of Singapore (NUS) Suzhou Research Institute, Suzhou Industrial Park, 215123 Suzhou, China

Abstract

Optical sensors, with great potential to convert invisible bioanalytical response into readable information, have been envisioned as a powerful platform for biological analysis and early diagnosis of diseases. However, the current extraction of sensing data is basically processed via a series of complicated and time-consuming calibrations between samples and reference, which inevitably introduce extra measurement errors and potentially annihilate small intrinsic responses. Here, we have proposed and experimentally demonstrated a calibration-free sensor for achieving high-precision biosensing detection, based on an optically controlled terahertz (THz) ultrafast metasurface. Photoexcitation of the silicon bridge enables the resonant frequency shifting from 1.385 to 0.825 THz and reaches the maximal phase variation up to 50° at 1.11 THz. The typical environmental measurement errors are completely eliminated in theory by normalizing the Fourier-transformed transmission spectra between ultrashort time delays of 37 ps, resulting in an extremely robust sensing device for monitoring the cancerous process of gastric cells. We believe that our calibration-free sensors with high precision and robust advantages can extend their implementation to study ultrafast biological dynamics and may inspire considerable innovations in the field of medical devices with nondestructive detection.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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