Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

Author:

Xia Menghang1,Huang Ruili1,Shi Qiang2,Boyd Windy A.3,Zhao Jinghua1,Sun Nuo4,Rice Julie R.3,Dunlap Paul E.3,Hackstadt Amber J.5,Bridge Matt F.5,Smith Marjolein V.5,Dai Sheng1,Zheng Wei1,Chu Pei-Hsuan1,Gerhold David1,Witt Kristine L.3,DeVito Michael3,Freedman Jonathan H.6,Austin Christopher P.1,Houck Keith A.7,Thomas Russell S.7,Paules Richard S.3,Tice Raymond R.3,Simeonov Anton1

Affiliation:

1. National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA

2. Division of Systems Biology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, Arkansas, USA

3. Division of the National Toxicology Program, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina, USA

4. National Heart, Lung, and Blood Institute, NIH, DHHS, Bethesda, Maryland, USA

5. Social & Scientific Systems, Inc., Durham, North Carolina, USA

6. Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, USA

7. National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

Publisher

Environmental Health Perspectives

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health

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