Synergistic anticancer effect of exogenous wild-typep53gene combined with 5-FU in human colon cancer resistant to 5-FUin vivo

Author:

Xie Qi,Wu Min-Yi,Zhang Ding-Xuan,Yang Yi-Ming,Wang Bao-Shuai,Zhang Jing,Xu Jin,Zhong Wei-De,Hu Jia-Ni

Publisher

Baishideng Publishing Group Inc.

Subject

Gastroenterology,General Medicine

Reference61 articles.

1. The Global Burden of Cancer 2013

2. 5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR/MTRR genotypes

3. RETRACTED ARTICLE: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy

4. Sun XX, Dai MS, Lu H. 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem 2007;282:8052-8059.

5. Subbarayan PR, Sarkar M, Nelson G, Benitez E, Singhal S, Ardalan B. Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance. Anticancer Res 2010;30:1149-1156.

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