Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat-Reference-Cited by-同舟云学术

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Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat

Published:2019-02 Issue:2 Volume:60 Page:412-420
ISSN:0022-2275
Container-title:Journal of Lipid Research
language:en
Short-container-title:Journal of Lipid Research

Author:

Metherel Adam H.,Lacombe R. J. Scott,Chouinard-Watkins Raphaël,Bazinet Richard P.

Funder

Natural Sciences and Engineering Research Council of Canada

Canada Research Chair

Ontario Graduate Scholarship

Peterborough KM Hunter Charitable Foundation

Fonds de Recherche du Québec – Santé

Publisher

Elsevier BV

Subject

Cell Biology,Endocrinology,Biochemistry

Reference33 articles.

1. The metabolism of 7,10,13,16,19-docosapentaenoic acid to 4,7,10,13,16,19-docosahexaenoic acid in rat liver is independent of a 4-desaturase;Voss;J. Biol. Chem.,1991

2. Peroxisomal beta-oxidation of polyunsaturated long chain fatty acids in human fibroblasts. The polyunsaturated and the saturated long chain fatty acids are retroconverted by the same acyl-CoA oxidase;Christensen;Scand. J. Clin. Lab. Invest. Suppl.,1993

3. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid;Moore;J. Lipid Res.,1995

4. Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3);Park;FEBS Lett.,2016

5. The fatty acid desaturase 2 (FADS2) gene product catalyzes Delta4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells;Park;FASEB J.,2015

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