Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Endocrinology,Biochemistry
Reference13 articles.
1. Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding;Yen;Nat. Med.,2009
2. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine;Yen;J. Biol. Chem.,2003
3. Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2;Cao;J. Biol. Chem.,2003
4. Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism;Shi;Am. J. Physiol. Endocrinol. Metab.,2009
5. Phenyl methanesulfonamide derivatives useful as MGAT - 2 inhibitors;Fernandez,2013
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2. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders;Journal of Medicinal Chemistry;2021-10-06
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