In vitroactivities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

Abstract

AbstractObjective:To determine the causative pathogens of otomycosis, and to evaluate thein vitroactivity of antifungal agents against these pathogens.Materials and methods:A total of 96 fungal isolate were taken from 92 patients suspected of otomycosis. Thein vitroactivity of fluconazole, itraconazole and voriconazole against otomycotic pathogens was tested using the E-test method.Results:The most common pathogen wasAspergillus fumigatus(40.6 per cent), followed byA niger(35.4 per cent),A flavus(12.5 per cent) andCandida albicans(11.5 per cent). AllAspergillusspecies were found to be resistant to fluconazole (minimum inhibitory concentration ≥256 µg/ml). The mean minimum inhibitory concentrations of voriconazole forA fumigatus,A niger,A flavusandC albicanswere significantly lower than those of itraconazole for the same pathogens.Conclusion:This study found that the most common otomycotic fungal pathogen wasA fumigatus, and that voriconazole had more potentin vitroactivity than itraconazole against allAspergillusspecies as well as againstC albicans.