Affiliation:
1. Departments of Pathology
2. Department of Epidemiology
3. Medicine, Roy J. and Lucille A. Carver College of Medicine
Abstract
ABSTRACT
The in vitro activity of itraconazole was determined against 7,299 isolates of
Candida
spp., 1,615 isolates of
Cryptococcus neoformans
, and 445 isolates of
Aspergillus
spp. obtained from over 200 medical centers worldwide. Itraconazole was active against all
Candida
spp. (96% of MICs were ≤1 μg/ml) with the exception of
C. glabrata
(77% of MICs were ≤1 μg/ml). Itraconazole inhibited 94% of
C. krusei
and 84% of other fluconazole-resistant
Candida
species, exclusive of
C. glabrata
, at a MIC of ≤1 μg/ml. Itraconazole was not active against fluconazole-resistant isolates of
C. glabrata
. Only modest activity was seen against
C. neoformans
(80% of MICs were ≤1 μg/ml); however, itraconazole showed excellent activity against
Aspergillus
spp. (94% of MICs were ≤1 μg/ml). These results provide an update on the antifungal activity of itraconazole against major opportunistic fungal pathogens. In light of the new intravenous formulation of itraconazole these data suggest that this agent remains a viable systemically active antifungal agent.
Publisher
American Society for Microbiology
Cited by
66 articles.
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