Author:
van Beijsterveldt Catharina E. M.,Groen-Blokhuis Maria,Hottenga Jouke Jan,Franić Sanja,Hudziak James J.,Lamb Diane,Huppertz Charlotte,de Zeeuw Eveline,Nivard Michel,Schutte Nienke,Swagerman Suzanne,Glasner Tina,van Fulpen Michelle,Brouwer Cyrina,Stroet Therese,Nowotny Dustin,Ehli Erik A.,Davies Gareth E.,Scheet Paul,Orlebeke Jacob F.,Kan Kees-Jan,Smit Dirk,Dolan Conor V.,Middeldorp Christel M.,de Geus Eco J. C.,Bartels Meike,Boomsma Dorret I.
Abstract
The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents.
Publisher
Cambridge University Press (CUP)
Subject
Genetics(clinical),Obstetrics and Gynaecology,Pediatrics, Perinatology, and Child Health
Cited by
154 articles.
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