Abstract
Abstract
This study aimed to investigate the association between n-3 PUFA and lung function. First, a cross-sectional study was conducted based on the National Health and Nutrition Examination Survey (NHANES) 2007–2012 data. n-3 PUFA intake was obtained from 24-h dietary recalls. A multivariable linear regression model was used to assess the observational associations of n-3 PUFA intake with lung function. Subsequently, a two-sample Mendelian randomisation (MR) was performed to estimate the potential causal effect of n-3 PUFA on lung function. Genetic instrumental variables were extracted from published genome-wide association studies. Summary statistics about n-3 PUFA was from UK Biobank. Inverse variance weighted was the primary analysis approach. The observational study did not demonstrate a significant association between n-3 PUFA intake and most lung function measures; however, a notable exception was observed with significant findings in the highest quartile for forced vital capacity (FVC) and % predicted FVC. The MR results also showed no causal effect of circulating n-3 PUFA concentration on lung function (forced expiratory volume in one second (FEV1), β = 0·01301, se = 0·01932, P = 0·5006; FVC, β = −0·001894, se = 0·01704, P = 0·9115; FEV1:FVC, β = 0·03118, se = 0·01743, P = 0·07359). These findings indicate the need for further investigation into the impact of higher n-3 PUFA consumption on lung health.
Publisher
Cambridge University Press (CUP)
Reference53 articles.
1. 18. Centers for Disease C, and Prevention The Examination Protocol and Data Collection Methods. –https://wwwn.cdc.gov/nchs/data/nhanes/2011–2012/manuals/mec_in_person_dietary_procedures_manual_jan_2012.pdf (accessed 7 February 2023).
2. Global initiative for chronic obstructive lung disease: the changes made;Patel;Cureus,2019
3. Education and lung cancer: a Mendelian randomization study;Zhou;Int J Epidemiol,2019
4. Fish consumption may limit the damage of smoking on the lung;Sharp;Am J Respir Crit Care Med,1994
5. Diet–gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases;Chilton;Nutrients,2014