Formation of lysinoalanine from individual bovine caseins

Abstract

SummaryThe formation of lysinoalanine, N-є-(2-amino-2-carboxyethyl)-L-lysine, by treatment of αs0-, αsl- and β-casein with alkali, has been studied. In all 3 proteins lysinoalanine was formed by reaction of lysyl residues with dehydroalanyl residues produced by alkaline degradation of those phosphoseryl residues which occupy isolated positions in the proteins' structures. The contribution to lysinoalanine production made by phosphoseryl residues which were arranged in clusters, as occurs in the sequence -Ser(P)-Ser(P)-Ser(P)-, was not significant.