Sex differences in Alzheimer's disease risk: are we looking at the wrong hormones?

Abstract

Two-thirds of individuals with Alzheimer's disease (AD) are women, owing largely to the fact that women outlive men (https://www.alz.org/downloads/facts_figures_2012.pdf). Women's increased longevity, however, is not sufficient to explain the fact that women are 1.5 times more likely than men to develop the disease (Gao et al., 1998). After age 80, the incidence of AD is much higher in women than in men, such that the proportion of women with AD is almost twice the proportion of men with the disease (e.g., Zandi et al., 2002; Plassman et al., 2007). Moreover, once diagnosed with AD, women decline more rapidly, both cognitively and functionally, compared to men (Ito et al., 2011; Tschanz et al., 2011).