Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically

Author:

Ma Junli1,Hong Ying1,Zheng Ningning1,Xie Guoxiang2,Lyu Yuanzhi3,Gu Yu1,Xi Chuchu1,Chen Linlin1,Wu Gaosong1,Li Yue4ORCID,Tao Xin1,Zhong Jing15,Huang Zhenzhen6,Wu Wenbin6,Yuan Lin6,Lin Min6,Lu Xiong6,Zhang Weidong17,Jia Wei89,Sheng Lili1,Li Houkai1

Affiliation:

1. Functional Metabolomic and Gut Microbiome Laboratory, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China

2. Human Metabolomics Institute, Inc, Shenzhen, Guangdong, China

3. Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, USA

4. Department of Endocrinology, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China

5. Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Affiliated Cent Hospital Huzhou University, Huzhou, China

6. Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China

7. Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, China

8. Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

9. Hong Kong Traditional Chinese Medicine Phenome Research Centre, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Program for Professor of Special Appointment (Eastern Scholar) & Shuguang Scholar

Shanghai Institutions of Higher Learning from Shanghai Municipal Education Commission

Publisher

Informa UK Limited

Subject

Infectious Diseases,Microbiology (medical),Gastroenterology,Microbiology

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