Abstract
SUMMARYSchistosomiasis and food-borne trematodiases are chronic parasitic diseases affecting millions of people mostly in the developing world. Additional drugs should be developed as only few drugs are available for treatment and drug resistance might emerge.In vitroandin vivowhole parasite screens represent essential components of the trematodicidal drug discovery cascade. This review describes the current state-of-the-art ofin vitroandin vivoscreening systems of the blood flukeSchistosoma mansoni, the liver flukeFasciola hepaticaand the intestinal flukeEchinostoma caproni. Examples ofin vitroandin vivoevaluation of compounds for activity are presented. To boost the discovery pipeline for these diseases there is a need to develop validated, robust high-throughputin vitrosystems with simple readouts.
Publisher
Cambridge University Press (CUP)
Subject
Infectious Diseases,Animal Science and Zoology,Parasitology
Cited by
119 articles.
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