Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection-Reference-Cited by-同舟云学术

Mitochondria as a Potential Target for the Development of Prophylactic and Therapeutic Drugs against Schistosoma mansoni Infection

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Talaam Keith Kiplangat¹²,Inaoka Daniel Ken³⁴⁵^ORCID,Hatta Takeshi⁶,Tsubokawa Daigo⁶,Tsuji Naotoshi⁶,Wada Minoru⁷,Saimoto Hiroyuki⁸,Kita Kiyoshi⁴⁵⁹,Hamano Shinjiro¹²¹⁰

Affiliation:

1. Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

2. Program for Nurturing Global Leaders in Tropical and Emerging Infectious Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

3. Department of Molecular Infection Dynamics, Shionogi Global Infectious Disease Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

4. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan

5. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

6. Department of Parasitology and Tropical Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

7. Division of Marine Biology and Dynamics, Faculty of Fisheries, Nagasaki University, Nagasaki, Japan

8. Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, Japan

9. Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

10. The Joint Usage/Research Center on Tropical Disease, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan

Abstract

The emergence of parasites resistant to praziquantel, the only therapeutic agent, and its ineffectiveness as a prophylactic agent (inactive against the migratory/juvenile Schistosoma mansoni ), make the development of new antischistosomal drugs urgent. The parasite’s mitochondrion is an attractive target for drug development, because this organelle is essential for survival throughout the parasite’s life cycle.

Funder

Infectious Disease Control from Science and Technology Research Partnership for Sustainable Development

Grant-in-Aid for Research on Priority Areas, Creative Scientific Research Grant and Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science

Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science

The Leading Initiative for Excellent Young Researchers Grant from Ministry of Education, Culture, Sports, Science and Technology

Japanese Initiative for Progress of Research on Infectious Diseases for Global Epidemics

Japanese Ministry of Health, Labour and Welfare

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00418-21

Reference90 articles.

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