cAMP-dependent protein kinase fromPlasmodium falciparum: an update

Abstract

SUMMARYOne of the most important public health problems in the world today is the emergence and dissemination of drug-resistant malaria parasites.Plasmodium falciparumis the causative agent of the most lethal form of human malaria. New anti-malarial strategies are urgently required, and their design and development require the identification of potential therapeutic targets. However, the molecular mechanisms controlling the life cycle of the malaria parasite are still poorly understood. The published genome sequence ofP. falciparumand previous studies have revealed that several homologues of eukaryotic signalling proteins, such as protein kinases, are relatively conserved. Protein kinases are now widely recognized as important drug targets in protozoan parasites. Cyclic AMP-dependent protein kinase (PKA) is implicated in numerous processes in mammalian cells, and the regulatory mechanisms of the cAMP pathway have been characterized.P. falciparumcAMP-dependent protein kinase plays an important role in the parasite's life cycle and thus represents an attractive target for the development of anti-malarial drugs. In this review, we focus on theP. falciparumcAMP/PKA pathway to provide new insights and an improved understanding of this signalling cascade.