Do intestinal parasites interfere with the seroepidemiologic surveillance ofSchistosoma mansoniinfection?

Author:

Alarcón De Noya B.,Colmenares C.,Losada S.,Fermin Z.,Masroua G.,Ruiz L.,Soto L.,Noya O.

Abstract

SUMMARYIn view of the known cross-reactivity of sera from patients with intestinal parasites to someSchistosoma mansoniantigens, field work was conducted in an area of Venezuela non-endemic for schistosomiasis using the routine immunoenzymatic assay (ELISA) with soluble egg antigen (SEA). False positive reactions represented 15·3% of the total population as determined by SEA–ELISA. SEA-immunoblotting of the false positive sera indicated that protein fractions of 91 and 80 kDa appear to be responsible for cross-reactivity. Sera from hookworm infected individuals produced a higher frequency and intensity of cross-reaction than other sera. SEA-fractions of 105, 54, 46, 42, 32, 25 and 15 kDa were the most specific.

Publisher

Cambridge University Press (CUP)

Subject

Infectious Diseases,Epidemiology

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