Mitigation of liquid–liquid phase separation of a monoclonal antibody by mutations of negative charges on the Fab surface
Author:
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference40 articles.
1. Evolution and emergence of therapeutic monoclonal antibodies;IN Filtz;What cardiologists need to know Circulation,2013
2. Therapeutic antibodies: Market considerations, disease targets and bioprocessing;JG Elvin;Int J Pharm,2013
3. The therapeutic monoclonal antibody market;DM Ecker;mAbs,2015
4. Aggregation and chemical modification of monoclonal antibodies under upstream processing conditions;S Dengl;Pharm Res,2013
5. Challenges in the development of high protein concentration formulations;SJ Shire;J Pharm Sci,2004
Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Predicting Colloidal Stability of High-Concentration Monoclonal Antibody Formulations in Common Pharmaceutical Buffers Using Improved Polyethylene Glycol Induced Protein Precipitation Assay;Molecular Pharmaceutics;2023-10-23
2. Non-specificity as the sticky problem in therapeutic antibody development;Nature Reviews Chemistry;2022-11-14
3. Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography;Journal of Chromatography A;2022-08
4. Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties;Molecular Pharmaceutics;2022-02-02
5. Formation of Transient Highly-Charged Mab Clusters Strengthens Interactions with Host Cell Proteins (Hcps) and Results in Poor Hcp Removal by Protein a Chromatography;SSRN Electronic Journal;2022
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3