Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics
Author:
Funder
National Institute of General Medical Science (US)
National Institute of General Medical Sciences
Office of AIDS Research
Publisher
Public Library of Science (PLoS)
Subject
Multidisciplinary
Reference54 articles.
1. The structural biology of HIV assembly;BK Ganser-Pornillos;Curr Opin Struct Biol,2008
2. Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV;E De Clercq;Int J Antimicrob Agents,2009
3. Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study;M May;BMJ,2011
4. Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy;MT May;AIDS,2014
5. 2015 Update of the Drug Resistance Mutations in HIV-1;AM Wensing;Top Antivir Med,2015
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